Infection-Resistant Prostheses

A new way to treat the periprosthetic joint infections.

Infection-Resistant Prostheses

Infection is one of the most devastating complications in orthopedic surgery. It costs a lot for both the patients and health care system, including the surgeons. Periprosthetic joint infection (PJI) is very difficult to treat and once treated, is not aasociated with an acceptable clinical and functional result, since this treatment usually involes a one- or two-stage prostetic revision. Previous attempts to resolve this problem have been focused on addition of antibiotics to the prosthetic materials, surface modification in the prosthesis by adding metals like silver or cupper or changing the prosthtic materials to titanium, have all failed.

We are trying to make a physical change in the surface of the prostheses to inhibit bacterial adhesion and biofilm formation.This will hopefully result in a prosthesis that once infected, acts like a native joint and there is no need to remove the infected prosthesis, which is the most catastrophic part of the treatment for PJI.